Panama City cruises

Find the perfect Panama City cruise for your next trip!

Prices include all applicable taxes and port fees

58 Panama City cruises

Prices include all applicable taxes and port fees

16 Night Repo

Norwegian Star
Norwegian Star Recommended Cruise
Departing from:San Diego, California
Ports of call:Cabo San Lucas, Mexico•Acapulco, Mexico•Puerto Quetzal, Guatemala•Puntarenas, Costa Rica•Panama City, Panama•Panama Canal, Panama•Cartagena, Colombia•Georgetown, Grand Cayman, Cayman Islands•Miami, Florida
Sailing dates:February 13, 2027

Bonus Offers:

  • Save $1,199 per person with this offer
  • Up to 50% off
Interior from $2,908 $1,709
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Panama Canal: Los Angeles To Miami

Brilliant Lady
Brilliant Lady Recommended Cruise
Departing from:Los Angeles, California
Ports of call:Cabo San Lucas, Mexico•Puerto Quetzal, Guatemala•Puntarenas, Costa Rica•Panama City, Panama•Cartagena, Colombia•Miami, Florida
Sailing dates:October 29, 2026•November 27, 2027

Bonus Offers:

  • Save $571 per person with this offer
  • Up to 35% off
Interior from $2,425 $1,854
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Endless Worlds, Our 128 Day Inaugural World Journey 2029

EXPLORA I
EXPLORA I Recommended Cruise
Departing from:Dubai, United Arab Emirates
Ports of call:Khasab, Oman•Bombay, India•Goa, India•Cochin, India•Male, Maldives•Colombo, Sri Lanka•Hobart, Australia•Phuket, Thailand•Langkawi, Malaysia•Singapore, Singapore•Surabaya, Java, Indonesia•Benoa (Bali), Indonesia
Sailing dates:January 6, 2029
Suite from $92,625/ pp
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10 Night Classic Panama Canal Passage

Viking Mars
Viking Mars Recommended Cruise
Departing from:Fort Lauderdale (Port Everglades), Florida
Ports of call:Merida, Mexico•Cozumel, Mexico•Belize City, Belize•Puerto Limon, Costa Rica•Colon, Panama•Panama City, Panama
Sailing dates:November 2027•January 2028•October 2028•November 2028•December 2028
Balcony from $3,799/ pp
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15 Night Repo

Norwegian Encore
Norwegian Encore Recommended Cruise
Departing from:Los Angeles, California
Ports of call:Cabo San Lucas, Mexico•Acapulco, Mexico•Puerto Quetzal, Guatemala•Puerto Caldera, Costa Rica•Panama City, Panama•Panama Canal, Panama•Cartagena, Colombia•Miami, Florida
Sailing dates:January 9, 2028

Bonus Offers:

  • Save $1,209 per person with this offer
  • Up to 50% off
Interior from $3,038 $1,829
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176 Night World Cruise

Azamara Onward
Azamara Onward Recommended Cruise
Departing from:Miami, Florida
Ports of call:Port of Oranjestad, Aruba, Caribbean•Willemstad, Curacao•Cartagena, Colombia•Panama Canal, Panama•Colon, Panama•Panama City, Panama•Manta (Quito), Ecuador•Callao (Lima), Peru•Easter Island, Chile•Pitcairn Island, United Kingdom•Fakarava, Tahiti•Moorea, French Polynesia
Sailing dates:January 5, 2028
Oceanview from $63,339/ pp
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10 Night Panama Canal Cruise

Oceania Marina
Oceania Marina Recommended Cruise
Departing from:Panama City, Panama
Ports of call:Cartagena, Colombia•Santa Marta, Colombia•Port of Oranjestad, Aruba, Caribbean•Willemstad, Curacao•Falmouth, Jamaica•Georgetown, Grand Cayman, Cayman Islands•Miami, Florida
Sailing dates:March 15, 2027
Interior from $3,899/ pp
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Endless Worlds, Our 108 Day Inaugural World Journey 2029

EXPLORA I
EXPLORA I Recommended Cruise
Departing from:Dubai, United Arab Emirates
Ports of call:Khasab, Oman•Bombay, India•Goa, India•Cochin, India•Male, Maldives•Colombo, Sri Lanka•Hobart, Australia•Phuket, Thailand•Langkawi, Malaysia•Singapore, Singapore•Surabaya, Java, Indonesia•Benoa (Bali), Indonesia
Sailing dates:January 6, 2029
Suite from $81,700/ pp
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10 Night Panama Canal Cruise

Oceania Marina
Oceania Marina Recommended Cruise
Departing from:Miami, Florida
Ports of call:Cozumel, Mexico•Costa Maya, Mexico•Harvest Caye, Belize•Santo Tomas de Castilla, Guatemala•Roatan, Honduras•Puerto Limon, Costa Rica•Panama City, Panama
Sailing dates:January 5•March 5, 2027
Interior from $3,299/ pp
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Endless Worlds, Our 112 Day Inaugural World Journey 2029

EXPLORA I
EXPLORA I Recommended Cruise
Departing from:Dubai, United Arab Emirates
Ports of call:Khasab, Oman•Bombay, India•Goa, India•Cochin, India•Male, Maldives•Colombo, Sri Lanka•Hobart, Australia•Phuket, Thailand•Langkawi, Malaysia•Singapore, Singapore•Surabaya, Java, Indonesia•Benoa (Bali), Indonesia
Sailing dates:January 6, 2029
Suite from $84,075/ pp
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Showing Results 10 of 58

About Panama City cruises

Cruises to or from Panama City sail mostly to Central America and the Panama Canal. Oceania, Azamara, Regent, and Viking Ocean offer these itineraries. Trips include 10- to 56-night itineraries with stops at Miami, Puerto Limon, and Cartagena, Colombia.

Sailings to or from Panama City run from October 2026 to February 2029, most often in January. Choose from interior, oceanview, balcony, and suite cabins. You can sail on Oceania Marina, Viking Mars, and Azamara Quest. Check out the sailings above to find a departure that suits your plans.

Frequently asked questions

Which ports do Panama City cruises visit?

Panama City itineraries include stops at Puerto Limon, Cozumel, and Cartagena, Colombia. 36 sailings stop at Puerto Limon.

Which cruise lines sail to or from Panama City?

Oceania, Azamara, Regent, and Viking Ocean all sail to or from Panama City.

Where do Panama City cruises leave from?

You can sail from Miami, Panama City, Los Angeles, and Fort Lauderdale (Port Everglades). Departures are most frequent from Miami.

Which ships sail to or from Panama City most often?

Ships sailing most often include Oceania Marina, Viking Mars, and Azamara Quest.

What kinds of cabins are available?

You can choose interior, oceanview, balcony, and suite cabins.

How many cruises and ships are sailing to or from Panama City?

There are currently 68 sailings on 18 ships. Departures run from October 2026 to February 2029.

What are the shortest and longest Panama City cruises?

The shortest trip is 9 nights, and the longest is 176 nights. Most trips last 10 to 56 nights.

How long are Panama City cruises?

Trips include 10- to 56-night itineraries.