Cruises from Santo Domingo

Find the perfect cruise from Santo Domingo for your next trip!

Prices include all applicable taxes and port fees

20 cruises from Santo Domingo

Prices include all applicable taxes and port fees

7 Night Caribbean And Antilles Cruise

Costa Favolosa
Costa Favolosa Great Deal Recommended Cruise
Departing from:Santo Domingo, Dominican Republic
Ports of call:Antigua, Antigua & Barbuda•Martinique Bay•Fort-de-France, Martinique•Pointe-a-Pitre, Guadeloupe•Sea Of Antilles Darkest Spot•Port of Basseterre, St. Kitts, St. Kitts and Nevis•Philipsburg, St. Maarten
Sailing dates:January 18•February 1, 2027

Bonus Offers:

  • Save $159 per person with this offer
Interior from $838 $679
View Itinerary

7 Night Caribbean And Antilles Cruise

Costa Favolosa
Costa Favolosa Great Deal Recommended Cruise
Departing from:Santo Domingo, Dominican Republic
Ports of call:Philipsburg, St. Maarten•Martinique Bay•Fort-de-France, Martinique•Pointe-a-Pitre, Guadeloupe•Sea Of Antilles Darkest Spot•Port of Basseterre, St. Kitts, St. Kitts and Nevis•Road Town, Tortola, B.V.I.
Sailing dates:January 11, 2027

Bonus Offers:

  • Save $180 per person with this offer
Interior from $948 $768
View Itinerary

7 Night Caribbean And Antilles Cruise

Costa Favolosa
Costa Favolosa Great Deal Recommended Cruise
Departing from:Santo Domingo, Dominican Republic
Ports of call:Antigua, Antigua & Barbuda•Martinique Bay•Fort-de-France, Martinique•Pointe-a-Pitre, Guadeloupe•Sea Of Antilles Darkest Spot•Port of Basseterre, St. Kitts, St. Kitts and Nevis•Road Town, Tortola, B.V.I.
Sailing dates:January 4•February 15, 22, 2027

Bonus Offers:

  • Save $167 per person with this offer
Interior from $896 $729
View Itinerary

7 Night Caribbean And Antilles Cruise

Costa Favolosa
Costa Favolosa Great Deal Recommended Cruise
Departing from:Santo Domingo, Dominican Republic
Ports of call:Martinique Bay•Fort-de-France, Martinique•Pointe-a-Pitre, Guadeloupe•Sea Of Antilles Darkest Spot•Port of Basseterre, St. Kitts, St. Kitts and Nevis•Antigua, Antigua & Barbuda•Road Town, Tortola, B.V.I.
Sailing dates:December 7, 14, 2026

Bonus Offers:

  • Save $167 per person with this offer
Interior from $896 $729
View Itinerary

7 Night Caribbean And Antilles Cruise

Costa Favolosa
Costa Favolosa Great Deal Recommended Cruise
Departing from:Santo Domingo, Dominican Republic
Ports of call:Martinique Bay•Fort-de-France, Martinique•Pointe-a-Pitre, Guadeloupe•Philipsburg, St. Maarten•Sea Of Antilles Darkest Spot•Port of Basseterre, St. Kitts, St. Kitts and Nevis•Road Town, Tortola, B.V.I.
Sailing dates:December 21, 2026

Bonus Offers:

  • Save $207 per person with this offer
Interior from $1,085 $878
View Itinerary

7 Night Caribbean And Antilles Cruise

Costa Favolosa
Costa Favolosa Great Deal Recommended Cruise
Departing from:Santo Domingo, Dominican Republic
Ports of call:Roseau, Dominica•Martinique Bay•Fort-de-France, Martinique•Pointe-a-Pitre, Guadeloupe•Sea Of Antilles Darkest Spot•Port of Basseterre, St. Kitts, St. Kitts and Nevis•Road Town, Tortola, B.V.I.
Sailing dates:January 25, 2027

Bonus Offers:

  • Save $199 per person with this offer
Interior from $1,050 $851
View Itinerary

7 Night Caribbean And Antilles Cruise

Costa Favolosa
Costa Favolosa Recommended Cruise
Departing from:Santo Domingo, Dominican Republic
Ports of call:Martinique Bay•Fort-de-France, Martinique•Pointe-a-Pitre, Guadeloupe•Roseau, Dominica•Sea Of Antilles Darkest Spot•Philipsburg, St. Maarten•Samana, Dominican Republic
Sailing dates:December 28, 2026

Bonus Offers:

  • Save $672 per person with this offer
Interior from $3,390 $2,718
View Itinerary

20 Night Ocean Cruises Cruise

Costa Favolosa
Costa Favolosa Recommended Cruise
Departing from:Santo Domingo, Dominican Republic
Ports of call:Philipsburg, St. Maarten•Martinique Bay•Fort-de-France, Martinique•Pointe-a-Pitre, Guadeloupe•Port of Basseterre, St. Kitts, St. Kitts and Nevis•Antigua, Antigua & Barbuda•Santa Cruz de Tenerife, Canary Islands•Tangier, Morocco•Malaga, Spain•Barcelona, Spain•Marseille, France•Savona (Genoa), Italy
Sailing dates:March 1, 2027

Bonus Offers:

  • Save $517 per person with this offer
Interior from $2,654 $2,137
View Itinerary

7 Night Caribbean And Antilles Cruise

Costa Favolosa
Costa Favolosa Recommended Cruise
Departing from:Santo Domingo, Dominican Republic
Ports of call:Pointe-a-Pitre, Guadeloupe•Fort-de-France, Martinique•Sea Of Antilles Darkest Spot•Port of Basseterre, St. Kitts, St. Kitts and Nevis•Antigua, Antigua & Barbuda•Road Town, Tortola, B.V.I.
Sailing dates:November 30, 2026

Bonus Offers:

  • Save $585 per person with this offer
Interior from $2,984 $2,399
View Itinerary

19 Night Ocean Cruises Cruise

Costa Favolosa
Costa Favolosa Recommended Cruise
Departing from:Santo Domingo, Dominican Republic
Ports of call:Philipsburg, St. Maarten•Martinique Bay•Fort-de-France, Martinique•Pointe-a-Pitre, Guadeloupe•Port of Basseterre, St. Kitts, St. Kitts and Nevis•Antigua, Antigua & Barbuda•Santa Cruz de Tenerife, Canary Islands•Tangier, Morocco•Malaga, Spain•Barcelona, Spain•Marseille, France
Sailing dates:March 1, 2027

Bonus Offers:

  • Save $405 per person with this offer
Interior from $2,092 $1,687
View Itinerary

Showing Results 10 of 20

About cruises from Santo Domingo

Cruises from Santo Domingo call at ports including Fort-de-France, Pointe-a-Pitre, and Antigua. Costa runs most of the sailings here. Trips include 7- to 17-night itineraries heading mostly to the Caribbean and Africa.

Sailings from Santo Domingo run from November 2026 to March 2028, most often in January. Choose from interior, oceanview, balcony, and suite cabins. You can sail on Costa Favolosa and Costa Serena. Take a look at the departure dates and itineraries above to find a sailing that fits your plans.

Frequently asked questions

Do cruises from Santo Domingo go to Fort-de-France?

Yes, 32 sailings from Santo Domingo stop at Fort-de-France. Of those, 25 are 7-night sailings.

Where do cruises from Santo Domingo go?

You can visit the Caribbean and Africa. Ports of call include Fort-de-France, Pointe-a-Pitre, and Antigua.

Which ships sail from Santo Domingo most often?

Ships sailing most often include Costa Favolosa and Costa Serena. Costa sails from Santo Domingo.

What kinds of cabins are available?

You can choose interior, oceanview, balcony, and suite cabins.

How many cruises and ships are sailing from Santo Domingo?

There are currently 32 sailings on 2 ships.

What are the shortest and longest cruises from Santo Domingo?

The shortest trip is 4 nights, and the longest is 20 nights. Most trips last 7 to 17 nights.

How long are cruises from Santo Domingo?

Trips include 7- to 17-night itineraries.

When do cruises from Santo Domingo sail?

Departures run from November 2026 to March 2028. Departures are most often in January.